LeBron James added 28 points and seven assists as the duo continues their recent dominance over the Pacers.
In the last three games of this series all that Miami won, LeBron and Wade outscored the Pacers starters by themselves 197-184.
The Heat were down 2-1 in this series after losing Chris Bosh in Game 1 and it looked like the Pacers could be poised to pull off the upset.
LeBron and Wade really stepped up in the final three games to lead Miami and take the series.
The Heat await the winner of Boston and Philadelphia who will play Game 7 of their series Saturday night. Game 1of the Eastern Conference Finals will be Monday night.